7‑OH Tolerance: What Researchers Need to Know About Mechanisms, Measurement, and Study Design
Understanding 7‑OH Tolerance: Pharmacology, Pathways, and Cross‑Tolerance 7‑OH tolerance refers to the diminished response observed after repeated exposures to 7‑hydroxymitragynine (often shortened to 7‑OH), a potent indole alkaloid known to act primarily at the mu‑opioid receptor (MOR). Although 7‑OH naturally occurs at low levels in certain Mitragyna speciosa plant materials, it is also formed in…